P-190: Regression of Endometrial Hyperplasia after Treatment with Drug and Conservative Treatment in Early Abortion: A Case Series Study

Background: The aim of the conservative treatment is the regression of the hyperplastic to normal endometrium. Conservative treatment of endometrial hyperplasia is based on the administration of agents with either antioestrogenic action or direct anti-proliferative effect on the endometrium. Progestagens have been used widely in the treatment of endometrial hyperplasias. Materials and Methods: 19 patients with recurrent abortion were enrolled in this trial at the Mother and Child Hospital. In the primary visit, transvaginal ultrasound performed for all patients. If endometrial thickness was more than 12 mm, Before initiating of treatment, endometrial biopcy was done. Then, the patients were divided to 4 groups: group I took ocp for 3 months, group II took 200 mg (BID) danazol for 3 months, group III took medroxyprogesterone, 10 mg/d for 3 cycles and group IV had conservative treatment. After ending the treatments, the patients were allowed to become pregnant.Results: Six of 7 patients with conservative treatment and 2 of 12 patients with drug treatment had abortion. 1 of 7 patients with conservative treatment and 10 of 12 patients with drug treatment had clinical pregnancy more than 12 weeks. The result of clinical pregnancy were statistically significant between conservative (14.3%) and drug treatment (83.3%) groups (p=0.006). Conclusion: The use of drug treatment compare with conservative treatment in recurrent abortion with endometrial hyperplasia patients statistically significantly improved the pregnancy rate and decrease early pregnancy loss.